PEGylation Science
PEG Performance
Polyethylene glycol (PEG) reagents are an essential and well-proven cornerstone of many modern therapeutics. Gannet BioChem has dedicated over 30 years to mastering the art and science of PEGylation.
Improve the Performance of Your Drug Substance
Over the years, PEGylation has consistently demonstrated its ability to transform and enhance the performance of drug substances. It has broad modality applications, including biologics, small molecules, peptides, and lipid nanoparticles (LNPs). With over 80 FDA-approved PEGylated drugs on the market, including the mRNA COVID-19 vaccines, the demand for reliable and innovative PEG reagents continues to grow.
The Transformative Benefits of PEGylation
PEGylation involves conjugating PEG (polyethylene glycol) to various types of drug substances with innovative PEG reagents, delivering transformative benefits that enhance a compound’s manufacturability and optimize efficacy for patients.
Improved bioavailability
in poorly soluble / difficult-to-formulate compounds
Improved pharmacokinetics (PK) and
pharmacodynamics (PD)
reducing renal clearance and extending drug half-life
Minimized toxicity and reduced immune response
by shielding epitopes and limiting neutralizing antibodies
Enhanced drug stability
including resistance to degradation by metabolic enzymes
Custom PEG Solutions for Complex Therapeutics
Gannet BioChem’s legacy and depth of experience with PEG reagents offer an unmatched level of expertise in the development, customization, and scale-up of PEG reagents—well-suited for complex therapeutics. We partner with customers to support the successful commercialization of cutting-edge therapies that deliver efficacy, safety, and other patient benefits.
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